After Destroy All Humans! Big Willy Unleashed, Crypto 138 has resigned his Presidency and Natalya has died because of her clone having only a four year life span, has crashed his old saucer into a casino's electronic ticker display while drunk, and was killed in the crash. After the crash, Pox has cloned Crypto 139, and they have taken over and re-opened the casino, called the "Space Dust," which they use to maintain a steady flow of cash and human DNA.